Macrolide Chemistry

This includes: 6-O-methylation of Erythromycin thiocyanate to give Clarithromycin. Ring Expansion of to yield Azithromycin 9-N-O-proteinion of Erythromycin thiocyanate to yield Roxithromycin.

Ketolides:
Alembic Pharmaceuticals Limited has plans to introduce the 3 and/or 11-Oxo derivatives of Erythromycin A.
We have also manufactured the following derivatives through various chemistries:
Roxithromycin related Substances:
Erythromycin E Oxime-HCLN-demethyl Roxithromycin
Decladinosyl RoxithromycinRoxithromycin B
Roxithromycin - 10(z)Erythromycin 10-(E)-[O-[[(2-methoxyethoxy)methoxy]methyl]oxime]
Roxithromycin C
2-O-[(2-methoxyethoxy)methyl erythromycin 10-(E)-[O-[[2-methoxy ethoxy)methoxy]methyl]oxime].
Clarithromycin related substances:
Clarithromycin-9-Oxime15-nor-clarithromycin
N-demethyl Clarithromycin6-O-methyl Clarithromycin 9-O-methyl Oxime
6-11,di-O-methyl ClarithromycinN-demethyl-N-formyl clarithromycin
6-12,di-O-methyl Clarithromycin 
Azithromycin Related Substances:
Erythromycin IminoetherDecladinosyl Azithromycin
AzaerythromycinN-methyl Azithromycin
Azaerythromycin B